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Insights into Lafora disease: Malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin

Lafora disease (LD) is a fatal form of progressive myoclonus epilepsy caused by recessive mutations in either a gene encoding a dual-specificity phosphatase, known as laforin, or a recently identified gene encoding the protein known as malin. Here, we demonstrate that malin is a single subunit E3 ub...

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Autori principali: Gentry, Matthew S., Worby, Carolyn A., Dixon, Jack E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1150849/
https://ncbi.nlm.nih.gov/pubmed/15930137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503285102
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