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Interaction between genetic susceptibility and early-life environmental exposure determines tumor-suppressor-gene penetrance
Gene–environment interactions are important determinants of cancer risk. Traditionally, gene–environment interactions are thought to contribute to tumor-suppressor-gene penetrance by facilitating or inhibiting the acquisition of additional somatic mutations required for tumorigenesis. Here, we demon...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2005
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1150843/ https://ncbi.nlm.nih.gov/pubmed/15937110 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503218102 |
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