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Gene transfer to human joints: Progress toward a gene therapy of arthritis

This article describes the clinical application of gene therapy to a nonlethal disease, rheumatoid arthritis (RA). Intraarticular transfer of IL-1 receptor antagonist (IL-1Ra) cDNA reduces disease in animal models of RA. Whether this procedure is safe and feasible in humans was addressed in a phase...

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Main Authors: Evans, Christopher H., Robbins, Paul D., Ghivizzani, Steven C., Wasko, Mary Chester, Tomaino, Matthew M., Kang, Richard, Muzzonigro, Thomas A., Vogt, Molly, Elder, Elaine M., Whiteside, Theresa L., Watkins, Simon C., Herndon, James H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2005
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1150836/
https://ncbi.nlm.nih.gov/pubmed/15939878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0502854102
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