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Gene transfer to human joints: Progress toward a gene therapy of arthritis

This article describes the clinical application of gene therapy to a nonlethal disease, rheumatoid arthritis (RA). Intraarticular transfer of IL-1 receptor antagonist (IL-1Ra) cDNA reduces disease in animal models of RA. Whether this procedure is safe and feasible in humans was addressed in a phase...

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Autores principales: Evans, Christopher H., Robbins, Paul D., Ghivizzani, Steven C., Wasko, Mary Chester, Tomaino, Matthew M., Kang, Richard, Muzzonigro, Thomas A., Vogt, Molly, Elder, Elaine M., Whiteside, Theresa L., Watkins, Simon C., Herndon, James H.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2005
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1150836/
https://ncbi.nlm.nih.gov/pubmed/15939878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0502854102
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