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Variant surface glycoprotein RNA interference triggers a precytokinesis cell cycle arrest in African trypanosomes

Trypanosoma brucei is a protozoan parasite that causes African sleeping sickness. T. brucei multiplies extracellularly in the bloodstream, relying on antigenic variation of a dense variant surface glycoprotein (VSG) coat to escape antibody-mediated lysis. We investigated the role of VSG in prolifera...

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Detalhes bibliográficos
Main Authors: Sheader, Karen, Vaughan, Sue, Minchin, James, Hughes, Katie, Gull, Keith, Rudenko, Gloria
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1150830/
https://ncbi.nlm.nih.gov/pubmed/15937117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501886102
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