Tick-Borne Langat/Mosquito-Borne Dengue Flavivirus Chimera, a Candidate Live Attenuated Vaccine for Protection against Disease Caused by Members of the Tick-Borne Encephalitis Virus Complex: Evaluation in Rhesus Monkeys and in Mosquitoes

Langat virus (LGT), strain TP21, a naturally avirulent tick-borne flavivirus, was used to construct a chimeric candidate virus vaccine which contained LGT genes for premembrane (preM) and envelope (E) glycoprotein and all other sequences derived from dengue type 4 virus (DEN4). The live virus vaccin...

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Detalles Bibliográficos

Publicado en:	J Virol
Autores principales:	Pletnev, Alexander G., Bray, Michael, Hanley, Kathryn A., Speicher, Jim, Elkins, Randy
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 2001
Materias:	Vaccines and Antiviral Agents
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC115070/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11483771/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.17.8259-8267.2001
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