Tick-Borne Langat/Mosquito-Borne Dengue Flavivirus Chimera, a Candidate Live Attenuated Vaccine for Protection against Disease Caused by Members of the Tick-Borne Encephalitis Virus Complex: Evaluation in Rhesus Monkeys and in Mosquitoes

Langat virus (LGT), strain TP21, a naturally avirulent tick-borne flavivirus, was used to construct a chimeric candidate virus vaccine which contained LGT genes for premembrane (preM) and envelope (E) glycoprotein and all other sequences derived from dengue type 4 virus (DEN4). The live virus vaccin...

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Autors principals: Pletnev, Alexander G., Bray, Michael, Hanley, Kathryn A., Speicher, Jim, Elkins, Randy
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2001
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC115070/
https://ncbi.nlm.nih.gov/pubmed/11483771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.17.8259-8267.2001
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