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Transplantation of spermatogonial stem cells isolated from leukemic mice restores fertility without inducing leukemia

More than 70% of patients survive childhood leukemia, but chemotherapy and radiation therapy cause irreversible impairment of spermatogenesis. Although autotransplantation of germ cells holds promise for restoring fertility, contamination by leukemic cells may induce relapse. In this study, we isola...

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Detalhes bibliográficos
Main Authors: Fujita, Kazutoshi, Ohta, Hiroshi, Tsujimura, Akira, Takao, Tetsuya, Miyagawa, Yasushi, Takada, Shingo, Matsumiya, Kiyomi, Wakayama, Teruhiko, Okuyama, Akihiko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2005
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1150287/
https://ncbi.nlm.nih.gov/pubmed/15965502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24189
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