Studies on the mechanism of hydroxymethylbilane synthase concerning the role of arginine residues in substrate binding.

The role of conserved arginine residues in hydroxymethylbilane synthase was investigated by replacing these residues in the enzyme from Escherichia coli with leucine residues by using site-directed mutagenesis. The kinetic parameters for these mutant enzymes and studies on the formation of intermedi...

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Hauptverfasser: Lander, M, Pitt, A R, Alefounder, P R, Bardy, D, Abell, C, Battersby, A R
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1991
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1150073/
https://ncbi.nlm.nih.gov/pubmed/2025226
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