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Possible role and mechanism of action of dissolved calcium in the degradation of bone collagen by lysosomal cathepsins and collagenase.
Equilibrium experiments with bone powder, at pH values ranging from 6.3 to 3.5, show a linear relation between log([Ca2+]/[Ca2+]0) (where [Ca2+]0 = 1 M-Ca2+) and pH, indicating that [Ca2+] could reach levels of 25 mM at pH 5 and 90 mM at pH 4. These elevated Ca2+ concentrations stimulated the lysis...
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
1990
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1149733/ https://ncbi.nlm.nih.gov/pubmed/2176466 |
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