Simian Virus 40 Vp1 DNA-Binding Domain Is Functionally Separable from the Overlapping Nuclear Localization Signal and Is Required for Effective Virion Formation and Full Viability

A DNA-binding domain (DBD) was identified on simian virus 40 (SV40) major capsid protein Vp1, and the domain's function in the SV40 life cycle was examined. The DBD was mapped by assaying various recombinant Vp1 proteins for DNA binding in vitro. The carboxy-terminal 58-residue truncated Vp1ΔC58 pen...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Li, Peggy P., Nakanishi, Akira, Shum, Dorothy, Sun, Peter C.-K., Salazar, Adler M., Fernandez, Cesar F., Chan, Sze-Wai, Kasamatsu, Harumi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2001
Assuntos:	Replication
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114967/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11462004/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.16.7321-7329.2001
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