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Positively charged retinoids are potent and selective inhibitors of the trans-cis isomerization in the retinoid (visual) cycle

In vertebrate retinal photoreceptors, photoisomerization of opsin-bound visual chromophore 11-cis-retinal to all-trans-retinal triggers phototransduction events. Regeneration of the chromophore is a critical step in restoring photoreceptors to their dark-adapted state. This regeneration process, cal...

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Autori principali: Golczak, Marcin, Kuksa, Vladimir, Maeda, Tadao, Moise, Alexander R., Palczewski, Krzysztof
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1149451/
https://ncbi.nlm.nih.gov/pubmed/15917330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503318102
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