Human Cytomegalovirus US2 Endoplasmic Reticulum-Lumenal Domain Dictates Association with Major Histocompatibility Complex Class I in a Locus-Specific Manner

The human cytomegalovirus-encoded US2 glycoprotein targets endoplasmic reticulum-resident major histocompatibility complex (MHC) class I heavy chains for rapid degradation by the proteasome. We demonstrate that the endoplasmic reticulum-lumenal domain of US2 allows tight interaction with class I mol...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Gewurz, Benjamin E., Wang, Evelyn W., Tortorella, Domenico, Schust, Danny J., Ploegh, Hidde L.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2001
Assuntos:	Pathogenesis and Immunity
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114925/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11333901/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.11.5197-5204.2001
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