Human Cytomegalovirus US2 Endoplasmic Reticulum-Lumenal Domain Dictates Association with Major Histocompatibility Complex Class I in a Locus-Specific Manner

The human cytomegalovirus-encoded US2 glycoprotein targets endoplasmic reticulum-resident major histocompatibility complex (MHC) class I heavy chains for rapid degradation by the proteasome. We demonstrate that the endoplasmic reticulum-lumenal domain of US2 allows tight interaction with class I mol...

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Detalhes bibliográficos
Main Authors: Gewurz, Benjamin E., Wang, Evelyn W., Tortorella, Domenico, Schust, Danny J., Ploegh, Hidde L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114925/
https://ncbi.nlm.nih.gov/pubmed/11333901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.11.5197-5204.2001
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