Enhancement of Sindbis Virus Self-Replicating RNA Vaccine Potency by Linkage of Herpes Simplex Virus Type 1 VP22 Protein to Antigen

Recently, self-replicating and self-limiting RNA vaccines (RNA replicons) have emerged as an important form of nucleic acid vaccines. Self-replicating RNA eventually causes lysis of transfected cells and does not raise the concern associated with naked DNA vaccines of integration into the host genom...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Cheng, Wen-Fang, Hung, Chien-Fu, Chai, Chee-Yin, Hsu, Keng-Fu, He, Liangmai, Ling, Morris, Wu, T.-C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2001
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC114820/
https://ncbi.nlm.nih.gov/pubmed/11160740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.5.2368-2376.2001
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