Activated Notch1 Can Transiently Substitute for EBNA2 in the Maintenance of Proliferation of LMP1-Expressing Immortalized B Cells

Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA2) and latent membrane protein 1 (LMP1) are essential for immortalization of human B cells by EBV. EBNA2 and activated Notch transactivate genes by interacting with the cellular transcription factor RBP-Jκ/CBF1. Therefore, EBNA2 can be regarded as a fu...

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Bibliographic Details
Main Authors: Höfelmayr, Heike, Strobl, Lothar J., Marschall, Gabriele, Bornkamm, Georg W., Zimber-Strobl, Ursula
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC114787/
https://ncbi.nlm.nih.gov/pubmed/11160707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.5.2033-2040.2001
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