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Clearance of the heavy and light polypeptide chains of human tissue-type plasminogen activator in rats.

In order to assess which part of the tissue-type plasminogen activator (t-PA) molecule should be (genetically) modified to obtain more-slowly-clearing mutants, two-chain t-PA and its isolated heavy and light chains were radiolabelled and injected into rats. The vast majority of t-PA and the heavy ch...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Rijken, D C, Emeis, J J
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1986
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1147186/
https://ncbi.nlm.nih.gov/pubmed/3099771
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