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An Attenuating Mutation in the 2A Protease of Swine Vesicular Disease Virus, a Picornavirus, Regulates Cap- and Internal Ribosome Entry Site-Dependent Protein Synthesis

Virulent and avirulent strains of swine vesicular disease virus (SVDV), a picornavirus, have been characterized previously. The major determinants for attenuation have been mapped to specific residues in the 1D-2A-coding region. The properties of the 2A proteases from the virulent and avirulent stra...

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Detalhes bibliográficos
Main Authors: Sakoda, Yoshihiro, Ross-Smith, Natalie, Inoue, Toru, Belsham, Graham J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114646/
https://ncbi.nlm.nih.gov/pubmed/11602706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.22.10643-10650.2001
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