A Chimeric Human-Bovine Parainfluenza Virus Type 3 Expressing Measles Virus Hemagglutinin Is Attenuated for Replication but Is Still Immunogenic in Rhesus Monkeys

The chimeric recombinant virus rHPIV3-N(B), a version of human parainfluenza virus type 3 (HPIV3) that is attenuated due to the presence of the bovine PIV3 nucleocapsid (N) protein open reading frame (ORF) in place of the HPIV3 ORF, was modified to encode the measles virus hemagglutinin (HA) inserte...

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Главные авторы: Skiadopoulos, Mario H., Surman, Sonja R., Riggs, Jeffrey M., Collins, Peter L., Murphy, Brian R.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology (ASM) 2001
Предметы:
Vaccines and Antiviral Agents
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC114626/
https://ncbi.nlm.nih.gov/pubmed/11581420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.21.10498-10504.2001
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