The Pathogenicity of Human Immunodeficiency Virus (HIV) Type 1 Nef in CD4C/HIV Transgenic Mice Is Abolished by Mutation of Its SH3-Binding Domain, and Disease Development Is Delayed in the Absence of Hck

The human immunodeficiency virus type 1 (HIV-1) Nef protein is an important determinant of AIDS pathogenesis. We have previously reported that HIV-1 Nef is responsible for the induction of a severe AIDS-like disease in CD4C/HIV transgenic (Tg) mice. To understand the molecular mechanisms of this Nef...

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Εκδόθηκε σε:	J Virol
Κύριοι συγγραφείς:	Hanna, Zaher, Weng, Xiaoduan, Kay, Denis G., Poudrier, Johanne, Lowell, Clifford, Jolicoeur, Paul
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	American Society for Microbiology (ASM) 2001
Θέματα:	Pathogenesis and Immunity
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114506/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11533201/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.19.9378-9392.2001
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