Recombinant Herpes Simplex Virus Type 1 Expressing Murine Interleukin-4 Is Less Virulent than Wild-Type Virus in Mice

The effect of interleukin-4 (IL-4) on herpes simplex virus type 1 (HSV-1) infection in mice was evaluated by construction of a recombinant HSV-1 expressing the gene for murine IL-4 in place of the latency-associated transcript (LAT). The mutant virus (HSV-IL-4) expressed high levels of IL-4 in cultu...

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Autores principales: Ghiasi, Homayon, Osorio, Yanira, Perng, Guey-Chuen, Nesburn, Anthony B., Wechsler, Steven L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2001
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC114471/
https://ncbi.nlm.nih.gov/pubmed/11533166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.19.9029-9036.2001
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