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Inhibition of uroporphyrinogen decarboxylase by halogenated biphenyls in chick hepatocyte cultures. Essential role for induction of cytochrome P-448.

Uroporphyrinogen decarboxylase (EC 4.1.1.37) activity was assayed in cultures of chick-embryo hepatocytes by the changes in composition of porphyrins accumulated after addition of excess 5-aminolaevulinate. Control cells accumulated mainly protoporphyrin, whereas cells treated with 3,4,3',4...

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Bibliografiske detaljer
Main Authors: Sinclair, P R, Bement, W J, Bonkovsky, H L, Sinclair, J F
Format: Artigo
Sprog:Inglês
Udgivet: 1984
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1144237/
https://ncbi.nlm.nih.gov/pubmed/6435605
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