Adeno-Associated Virus Serotype 4 (AAV4) and AAV5 Both Require Sialic Acid Binding for Hemagglutination and Efficient Transduction but Differ in Sialic Acid Linkage Specificity

Adeno-associated virus serotype 4 (AAV4) and AAV5 have different tropisms compared to AAV2 and to each other. We recently reported that α2-3 sialic acid is required for AAV5 binding and transduction. In this study, we characterized AAV4 binding and transduction and found it also binds sialic acid, b...

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Autores principales: Kaludov, Nikola, Brown, Kevin E., Walters, Robert W., Zabner, Joseph, Chiorini, John A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2001
Materias:
Virus-Cell Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC114416/
https://ncbi.nlm.nih.gov/pubmed/11435568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.15.6884-6893.2001
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