Interleukin-12 (IL-12) and IL-18 Are Important in Innate Defense against Genital Herpes Simplex Virus Type 2 Infection in Mice but Are Not Required for the Development of Acquired Gamma Interferon-Mediated Protective Immunity

Using a combination of gene-targeted mice and neutralizing antibodies, we showed that interleukin-12 (IL-12) and IL-18 are important in the innate control of genital herpes simplex virus type 2 infection but were not found to be critical, either singly or in combination, for the development of a pro...

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Detalhes bibliográficos
Main Authors: Harandi, Ali M., Svennerholm, Bo, Holmgren, Jan, Eriksson, Kristina
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114395/
https://ncbi.nlm.nih.gov/pubmed/11413339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.14.6705-6709.2001
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