Biologic Studies of Chimeras of Highly and Moderately Virulent Molecular Clones of Simian Immunodeficiency Virus SIVsmPBj Suggest a Critical Role for Envelope in Acute AIDS Virus Pathogenesis

Previous studies identified three molecular clones of the acutely pathogenic SIVsmPBj strain that varied in terms of relative in vivo pathogenicity. One clone, SIVsmPBj6.6, reproducibly induced a rapidly fatal disease in pigtailed macaques. In contrast, a highly related clone (SIVsmPBj6.9) was only...

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Εκδόθηκε σε:	J Virol
Κύριοι συγγραφείς:	Haddrick, Malcolm, Brown, Charles R., Plishka, Ronald, Buckler-White, Alicia, Hirsch, Vanessa M., Ginsberg, Harold
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	American Society for Microbiology (ASM) 2001
Θέματα:	Pathogenesis and Immunity
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114388/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11413332/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.14.6645-6659.2001
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