Biologic Studies of Chimeras of Highly and Moderately Virulent Molecular Clones of Simian Immunodeficiency Virus SIVsmPBj Suggest a Critical Role for Envelope in Acute AIDS Virus Pathogenesis

Previous studies identified three molecular clones of the acutely pathogenic SIVsmPBj strain that varied in terms of relative in vivo pathogenicity. One clone, SIVsmPBj6.6, reproducibly induced a rapidly fatal disease in pigtailed macaques. In contrast, a highly related clone (SIVsmPBj6.9) was only...

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Autori principali: Haddrick, Malcolm, Brown, Charles R., Plishka, Ronald, Buckler-White, Alicia, Hirsch, Vanessa M., Ginsberg, Harold
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
Soggetti:
Pathogenesis and Immunity
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC114388/
https://ncbi.nlm.nih.gov/pubmed/11413332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.14.6645-6659.2001
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