Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia

Disrupted-in-schizophrenia 1 (DISC1) is a promising schizophrenia candidate gene expressed predominantly within the hippocampus. We typed 12 single-nucleotide polymorphisms (SNPs) that covered the DISC1 gene. A three-SNP haplotype [hCV219779 (C)-rs821597 (G)-rs821616 (A)] spanning 83 kb of the gene...

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Main Authors: Callicott, Joseph H., Straub, Richard E., Pezawas, Lukas, Egan, Michael F., Mattay, Venkata S., Hariri, Ahmad R., Verchinski, Beth A., Meyer-Lindenberg, Andreas, Balkissoon, Rishi, Kolachana, Bhaskar, Goldberg, Terry E., Weinberger, Daniel R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2005
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1143583/
https://ncbi.nlm.nih.gov/pubmed/15939883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0500515102
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