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Rearrangement of the Genes of Vesicular Stomatitis Virus Eliminates Clinical Disease in the Natural Host: New Strategy for Vaccine Development

Gene expression among the nonsegmented negative-strand RNA viruses is controlled by distance from the single transcriptional promoter, so the phenotypes of these viruses can be systematically manipulated by gene rearrangement. We examined the potential of gene rearrangement as a means to develop liv...

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Detalhes bibliográficos
Main Authors: Flanagan, E. Brian, Zamparo, Joann M., Ball, L. Andrew, Rodriguez, Luis L., Wertz, Gail W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114326/
https://ncbi.nlm.nih.gov/pubmed/11390612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.13.6107-6114.2001
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