Exploitation of the Low Fidelity of Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase and the Nucleotide Composition Bias in the HIV-1 Genome To Alter the Drug Resistance Development of HIV

The RNA genome of the lentivirus human immunodeficiency virus type 1 (HIV-1) is significantly richer in adenine nucleotides than the statistically equal distribution of the four different nucleotides that is expected. This compositional bias may be due to the guanine-to-adenine (G→A) nucleotide hype...

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Detalhes bibliográficos
Main Authors: Balzarini, Jan, Camarasa, Maria-José, Pérez-Pérez, Maria-Jesus, San-Félix, Ana, Velázquez, Sonsoles, Perno, Carlo-Federico, De Clercq, Erik, Anderson, John N., Karlsson, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114293/
https://ncbi.nlm.nih.gov/pubmed/11390579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.13.5772-5777.2001
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