Virus Reconstituted from Infectious Bacterial Artificial Chromosome (BAC)-Cloned Murine Gammaherpesvirus 68 Acquires Wild-Type Properties In Vivo Only after Excision of BAC Vector Sequences

We studied the in vivo biological properties of viruses reconstituted from the genome of murine gammaherpesvirus 68 (MHV-68) cloned as an infectious bacterial artificial chromosome (BAC). Recombinant virus RγHV68A98.01, containing BAC vector sequences, is attenuated in vivo as determined by (i) vira...

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הוצא לאור ב:	J Virol
Principais autores:	Adler, Heiko, Messerle, Martin, Koszinowski, Ulrich H.
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	American Society for Microbiology (ASM) 2001
נושאים:	Pathogenesis and Immunity
גישה מקוונת:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114283/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11356978/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.12.5692-5696.2001
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