Telomerase Activation by Human Papillomavirus Type 16 E6 Protein: Induction of Human Telomerase Reverse Transcriptase Expression through Myc and GC-Rich Sp1 Binding Sites

High-risk human papillomaviruses (HPVs) immortalize keratinocytes by disrupting the retinoblastoma protein (Rb)/p16 pathway and activating telomerase. The E7 oncoprotein targets Rb, while the E6 oncoprotein induces telomerase activity in human keratinocytes. This study has examined the mechanism by...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Oh, Stephen T., Kyo, Saturo, Laimins, Laimonis A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2001
Assuntos:	Virus-Cell Interactions
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114268/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11356963/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.12.5559-5566.2001
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