Telomerase Activation by Human Papillomavirus Type 16 E6 Protein: Induction of Human Telomerase Reverse Transcriptase Expression through Myc and GC-Rich Sp1 Binding Sites

High-risk human papillomaviruses (HPVs) immortalize keratinocytes by disrupting the retinoblastoma protein (Rb)/p16 pathway and activating telomerase. The E7 oncoprotein targets Rb, while the E6 oncoprotein induces telomerase activity in human keratinocytes. This study has examined the mechanism by...

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Detalles Bibliográficos
Main Authors: Oh, Stephen T., Kyo, Saturo, Laimins, Laimonis A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2001
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC114268/
https://ncbi.nlm.nih.gov/pubmed/11356963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.12.5559-5566.2001
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