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Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression

The ecotropic viral integration site-1 (Evi1) is an oncogenic transcription factor in murine and human myeloid leukemia. We herein show that Evi1 is predominantly expressed in hematopoietic stem cells (HSCs) in embryos and adult bone marrows, suggesting a physiological role of Evi1 in HSCs. We there...

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Bibliografische gegevens
Hoofdauteurs: Yuasa, Hiromi, Oike, Yuichi, Iwama, Atsushi, Nishikata, Ichiro, Sugiyama, Daisuke, Perkins, Archibald, Mucenski, Michael L, Suda, Toshio, Morishita, Kazuhiro
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2005
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1142611/
https://ncbi.nlm.nih.gov/pubmed/15889140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600679
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