Herpes Simplex Virus IE63 (ICP27) Protein Interacts with Spliceosome-Associated Protein 145 and Inhibits Splicing prior to the First Catalytic Step

The multifunctional herpes simplex virus type 1 (HSV-1) protein IE63 (ICP27) interacts with the essential pre-mRNA splicing factor, spliceosome-associated protein 145 (SAP145), and in infected cells IE63 and SAP145 colocalize. This interaction was reduced or abrogated completely using extracts from...

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Detalhes bibliográficos
Main Authors: Bryant, H. E., Wadd, S. E., Lamond, A. I., Silverstein, S. J., Clements, J. B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114182/
https://ncbi.nlm.nih.gov/pubmed/11287586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.9.4376-4385.2001
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