Muscle-Specific Overexpression of the Adenovirus Primary Receptor CAR Overcomes Low Efficiency of Gene Transfer to Mature Skeletal Muscle

Significant levels of adenovirus (Ad)-mediated gene transfer occur only in immature muscle or in regenerating muscle, indicating that a developmentally regulated event plays a major role in limiting transgene expression in mature skeletal muscle. We have previously shown that in developing mouse mus...

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Detalhes bibliográficos
Main Authors: Nalbantoglu, J., Larochelle, N., Wolf, E., Karpati, G., Lochmuller, H., Holland, P. C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114173/
https://ncbi.nlm.nih.gov/pubmed/11287577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.9.4276-4282.2001
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