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Construction and In Vitro Properties of a Series of Attenuated Simian Immunodeficiency Viruses with All Accessory Genes Deleted

We have generated simplified simian immunodeficiency virus (SIV) constructs lacking the nef, vpr, vpx, vif, tat, and rev genes (Δ6 viruses). To accomplish this, we began with an infectious molecular clone of SIV, i.e. SIVmac239, and replaced the deleted segments with three alternate elements: (i) a...

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Udgivet i:J Virol
Principais autores: Guan, Yongjun, Whitney, James B., Detorio, Mervi, Wainberg, Mark A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2001
Fag:
Replication
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114151/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11287555/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.9.4056-4067.2001
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