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Construction and In Vitro Properties of a Series of Attenuated Simian Immunodeficiency Viruses with All Accessory Genes Deleted

We have generated simplified simian immunodeficiency virus (SIV) constructs lacking the nef, vpr, vpx, vif, tat, and rev genes (Δ6 viruses). To accomplish this, we began with an infectious molecular clone of SIV, i.e. SIVmac239, and replaced the deleted segments with three alternate elements: (i) a...

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Bibliografiset tiedot
Päätekijät: Guan, Yongjun, Whitney, James B., Detorio, Mervi, Wainberg, Mark A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2001
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Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC114151/
https://ncbi.nlm.nih.gov/pubmed/11287555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.9.4056-4067.2001
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