Quintuple Deglycosylation Mutant of Simian Immunodeficiency Virus SIVmac239 in Rhesus Macaques: Robust Primary Replication, Tightly Contained Chronic Infection, and Elicitation of Potent Immunity against the Parental Wild-Type Strain

We previously generated a mutant of simian immunodeficiency virus (SIV) lacking 5 of a total of 22 N-glycans in its external envelope protein gp120 with no impairment in viral replication capability and infectivity in tissue culture cells. Here, we infected rhesus macaques with this mutant and found...

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Hlavní autoři: Mori, Kazuyasu, Yasutomi, Yasuhiro, Ohgimoto, Shinji, Nakasone, Tadashi, Takamura, Shiki, Shioda, Tatsuo, Nagai, Yoshiyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2001
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC114147/
https://ncbi.nlm.nih.gov/pubmed/11287551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.9.4023-4028.2001
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