Loss of a Single N-Linked Glycan Allows CD4-Independent Human Immunodeficiency Virus Type 1 Infection by Altering the Position of the gp120 V1/V2 Variable Loops

The gp120 envelope glycoprotein of primary human immunodeficiency virus type 1 (HIV-1) promotes virus entry by sequentially binding CD4 and the CCR5 chemokine receptor on the target cell. Previously, we adapted a primary HIV-1 isolate, ADA, to replicate in CD4-negative canine cells expressing human...

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Detalhes bibliográficos
Main Authors: Kolchinsky, Peter, Kiprilov, Enko, Bartley, Peter, Rubinstein, Roee, Sodroski, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114136/
https://ncbi.nlm.nih.gov/pubmed/11238869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.7.3435-3443.2001
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