Loss of a Single N-Linked Glycan Allows CD4-Independent Human Immunodeficiency Virus Type 1 Infection by Altering the Position of the gp120 V1/V2 Variable Loops

The gp120 envelope glycoprotein of primary human immunodeficiency virus type 1 (HIV-1) promotes virus entry by sequentially binding CD4 and the CCR5 chemokine receptor on the target cell. Previously, we adapted a primary HIV-1 isolate, ADA, to replicate in CD4-negative canine cells expressing human...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Kolchinsky, Peter, Kiprilov, Enko, Bartley, Peter, Rubinstein, Roee, Sodroski, Joseph
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2001
Assuntos:	Replication
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114136/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11238869/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.7.3435-3443.2001
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