Reduced Genomic Cytosine Methylation and Defective Cellular Differentiation in Embryonic Stem Cells Lacking CpG Binding Protein

Cytosine methylation at CpG dinucleotides is a critical epigenetic modification of mammalian genomes. CpG binding protein (CGBP) exhibits a unique DNA-binding specificity for unmethylated CpG motifs and is essential for early murine development. Embryonic stem cell lines deficient for CGBP were gene...

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Main Authors: Carlone, Diana L., Lee, Jeong-Heon, Young, Suzanne R. L., Dobrota, Erika, Butler, Jill Sergesketter, Ruiz, Joseph, Skalnik, David G.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2005
Assuntos:
Chromosome Structure and Dynamics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1140577/
https://ncbi.nlm.nih.gov/pubmed/15923607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.12.4881-4891.2005
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