Biological Cost of Single and Multiple Norfloxacin Resistance Mutations in Escherichia coli Implicated in Urinary Tract Infections

Resistance to fluoroquinolones in urinary tract infection (UTIs) caused by Escherichia coli is associated with multiple mutations, typically those that alter DNA gyrase and DNA topoisomerase IV and those that regulate AcrAB-TolC-mediated efflux. We asked whether a fitness cost is associated with the...

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Библиографические подробности
Главные авторы: Lindgren, Patricia Komp, Marcusson, Linda L., Sandvang, Dorthe, Frimodt-Møller, Niels, Hughes, Diarmaid
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2005
Предметы:
Mechanisms of Resistance
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1140522/
https://ncbi.nlm.nih.gov/pubmed/15917531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.6.2343-2351.2005
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