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Diacylglycerol kinase ι regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signaling
To study the physiological function of diacylglycerol (DAG) kinase ι (DGKι), which converts DAG to phosphatidic acid, we deleted this gene in mice. In contrast to previous studies showing that DGK isoforms decrease Ras activity, signaling downstream of Ras in embryonic fibroblasts was significantly...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1140424/ https://ncbi.nlm.nih.gov/pubmed/15894621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0500663102 |
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