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Association of diacylglycerol kinase ζ with protein kinase C α: spatial regulation of diacylglycerol signaling

Activation of PKC depends on the availability of DAG, a signaling lipid that is tightly and dynamically regulated. DAG kinase (DGK) terminates DAG signaling by converting it to phosphatidic acid. Here, we demonstrate that DGKζ inhibits PKCα activity and that DGK activity is required for this inhibit...

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Bibliografiset tiedot
Päätekijät: Luo, Bai, Prescott, Stephen M., Topham, Matthew K.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Rockefeller University Press 2003
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173768/
https://ncbi.nlm.nih.gov/pubmed/12629049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200208120
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