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Regulatory on/off minimization of metabolic flux changes after genetic perturbations

Predicting the metabolic state of an organism after a gene knockout is a challenging task, because the regulatory system governs a series of transient metabolic changes that converge to a steady-state condition. Regulatory on/off minimization (ROOM) is a constraint-based algorithm for predicting the...

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Hlavní autoři: Shlomi, Tomer, Berkman, Omer, Ruppin, Eytan
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2005
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1140402/
https://ncbi.nlm.nih.gov/pubmed/15897462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406346102
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