A Two-Hybrid Screen of the Yeast Proteome for Hsp90 Interactors Uncovers a Novel Hsp90 Chaperone Requirement in the Activity of a Stress-Activated Mitogen-Activated Protein Kinase, Slt2p (Mpk1p)

The Hsp90 chaperone cycle catalyzes the final activation step of several important eukaryotic proteins (Hsp90 “clients”). Although largely a functional form of Hsp90, an Hsp90-Gal4p DNA binding domain fusion (Hsp90-BD) displays no strong interactions in the yeast two-hybrid system, consistent with a...

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Main Authors: Millson, Stefan H., Truman, Andrew W., King, Victoria, Prodromou, Chrisostomos, Pearl, Laurence H., Piper, Peter W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1140089/
https://ncbi.nlm.nih.gov/pubmed/15879519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.4.5.849-860.2005
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