Nonmyeloablative Immunosuppressive Regimen Prolongs In Vivo Persistence of Gene-Modified Autologous T Cells in a Nonhuman Primate Model

The in vivo persistence of gene-modified cells can be limited by host immune responses to transgene-encoded proteins. In this study we evaluated in a nonhuman primate model whether the administration of a nonmyeloablative regimen consisting of low-dose total-body irradiation with 200 cGy followed by...

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Hlavní autoři: Berger, Carolina, Huang, Meei-Li, Gough, Michael, Greenberg, Philip D., Riddell, Stanley R., Kiem, Hans-Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2001
Témata:
Gene Therapy
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC113976/
https://ncbi.nlm.nih.gov/pubmed/11134293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.2.799-808.2001
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