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In Vivo Attenuation of Simian Immunodeficiency Virus by Disruption of a Tyrosine-Dependent Sorting Signal in the Envelope Glycoprotein Cytoplasmic Tail

Attenuated simian immunodeficiency viruses (SIVs) have been described that produce low levels of plasma virion RNA and exhibit a reduced capacity to cause disease. These viruses are particularly useful in identifying viral determinants of pathogenesis. In the present study, we show that mutation of...

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Udgivet i:J Virol
Principais autores: Fultz, Patricia N., Vance, Patricia J., Endres, Michael J., Tao, Binli, Dvorin, Jeffrey D., Davis, Ian C., Lifson, Jeffrey D., Montefiori, David C., Marsh, Mark, Malim, Michael H., Hoxie, James A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2001
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC113922/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11119598/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.1.278-291.2001
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