Alteration of Zinc-Binding Residues of Simian Immunodeficiency Virus p8(NC) Results in Subtle Differences in Gag Processing and Virion Maturation Associated with Degradative Loss of Mutant NC

In all retroviruses analyzed to date (except for the spumaretroviruses), the Zn(2+)-coordinating residues of nucleocapsid (NC) perform or assist in crucial reactions necessary to complete the retrovirus life cycle. Six replication-defective mutations have been engineered in the two NC Zn(2+) fingers...

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Bibliographic Details
Main Authors: Yovandich, Jason L., Chertova, Elena N., Kane, Brad P., Gagliardi, Tracy D., Bess, Julian W., Sowder, Raymond C., Henderson, Louis E., Gorelick, Robert J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Structure and Assembly
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC113904/
https://ncbi.nlm.nih.gov/pubmed/11119580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.1.115-124.2001
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