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Excess-substrate inhibition in enzymology and high-dose inhibition in pharmacology: a reinterpretation

A kinetic model, called the Recovery Model, which incorporates an obligatory recovery phase of fixed duration (tr) in the operation cycle of a macromolecule (enzyme, receptor) is proposed. Binding of a ligand (substrate, agonist) during tr disturbs the recovery process and causes inhibition (substra...

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Detalhes bibliográficos
Autor principal: Kühl, P W
Formato: Artigo
Idioma:Inglês
Publicado em: 1994
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1137998/
https://ncbi.nlm.nih.gov/pubmed/8129717
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