Site-directed mutagenesis of the putative active site of human 17 beta-hydroxysteroid dehydrogenase type 1.

Several amino acid residues (Cys54, Tyr155, His210, His213 and His221) at a putative catalytic site of human 17 beta-hydroxysteroid dehydrogenase type 1 were mutated to Ala. Replacement of His221 by Ala remarkably reduced the catalytic activity, which resulted from a change of both the Km and the Vm...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Puranen, T J, Poutanen, M H, Peltoketo, H E, Vihko, P T, Vihko, R K
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1994
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1137484/
https://ncbi.nlm.nih.gov/pubmed/7998947
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