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Agonist-induced down-regulation of platelet-activating factor receptor gene expression in U937 cells.

Prolonged exposure (8-24 h) of human promonocytic U937 cells to 100 nM 1-O-hexadecyl-2-N-methylcarbamyl-sn-glycero-3-phosphocholine (carbarmyl-PAF), a non-metabolizable analogue of platelet-activating factor (PAF), reduced the numbers of PAF receptors by 50-75%, as determined by the radioligand-bind...

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Main Authors: Chau, L Y, Peck, K, Yen, H H, Wang, J Y
Formato: Artigo
Idioma:Inglês
Publicado: 1994
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1137072/
https://ncbi.nlm.nih.gov/pubmed/7519853
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